Table 2. Diagnostic performance of presentation high sensitivity cardiac troponin I for myocardial infarction by age group and threshold.
| Age group (years) |
TP | FP | TN | FN | Sensitivity (95% CI) |
Specificity (95% CI) |
PPV (95% CI) |
NPV (95% CI) |
Rule-in (%) |
AUC (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| Sex-specific 99th centile* | ||||||||||
| <50 | 346 | 203 | 11739 | 91 | 79.2 (75.5-82.9) | 98.3 (98.1-98.5) | 63.0 (59.1-67.1) | 99.2 (99.1-99.4) | 4.4 | 0.89 (0.87-0.91) |
| 50-74 | 2088 | 889 | 18902 | 501 | 80.6 (79.2-82.1) | 95.5 (95.2-95.8) | 70.1 (68.5-71.8) | 97.4 (97.2-97.6) | 13.3 | 0.88 (0.87-0.89) |
| ≥75 | 1758 | 1653 | 7869 | 396 | 81.6 (79.9-83.2) | 82.6 (81.9-83.4) | 51.6 (49.8-53.2) | 95.2 (94.7-95.7) | 29.2 | 0.82 (0.79-0.81) |
| Overall | 4192 | 2745 | 38510 | 988 | 80.9 (79.8-82.0) | 93.3 (93.1-93.6) | 60.4 (59.3-61.6) | 97.5 (97.3-97.6) | 14.9 | 0.87 (0.87-0.88) |
| Age-adjusted 99th centile thresholds† | ||||||||||
| <50 | 346 | 203 | 11739 | 91 | 79.2 (75.5-82.9) | 98.3 (98.1-98.5) | 63.0 (59.1-67.1) | 99.2 (99.1-99.4) | 4.4 | 0.89 (0.87-0.91) |
| 50-74 | 1878 | 719 | 19072 | 711 | 72.5 (70.8-74.2) | 96.4 (96.1-96.6) | 72.3 (70.6-74.0) | 96.4 (96.1-96.7) | 11.6 | 0.84 (0.84-0.86) |
| ≥75 | 1203 | 827 | 8695 | 951 | 55.9 (53.5-57.9) | 91.3 (90.8-91.9) | 59.3 (57.1-61.4) | 90.1 (89.5-90.7) | 17.4 | 0.74 (0.73-0.75) |
| Overall | 3427 | 1749 | 39506 | 1753 | 66.2 (64.9-67.4) | 95.8 (95.6-95.9) | 66.2 (64.9-67.5) | 95.8 (95.6-95.9) | 11.1 | 0.81 (0.80-0.82) |
| Universal rule-in threshold (>64 ng/L) | ||||||||||
| <50 | 258 | 125 | 11817 | 179 | 59.0 (54.2-63.4) | 99.0 (98.8-99.1) | 67.4 (62.6-71.8) | 98.5 (98.3-98.7) | 3.1 | 0.79 (0.77-0.81) |
| 50-74 | 1435 | 445 | 19346 | 1154 | 55.4 (53.5-57.2) | 97.7 (97.5-98.0) | 76.3 (74.4-78.2) | 94.4 (94.1-94.7) | 8.4 | 0.77 (0.76-0.78) |
| ≥75 | 1079 | 693 | 8829 | 1075 | 50.1 (48.0-52.2) | 92.7 (92.2-93.2) | 60.9 (58.7-63.1) | 89.1 (88.5-89.7) | 15.2 | 0.71 (0.70-0.73) |
| Overall | 2772 | 1263 | 39992 | 2408 | 53.5 (52.2-54.9) | 96.9 (96.8-97.1) | 68.7 (67.3-70.2) | 94.3 (94.1-94.5) | 8.7 | 0.75 (0.75-0.76) |
Presented as number or % (95% confidence intervals) as appropriate.
*
Sex-specific 99th centile = 34 ng/L men, 16 ng/L women.
†
Age-adjusted thresholds = age <60: >32 ng/L men, >16 ng/L women; age 60-69: > 42 ng/L men, >17 ng/L women; age ≥70: 86 ng/L men, 39 ng/L women
Abbreviations: AUC = Area under the curve, FN=false negatives, FP=false positives, NPV = negative predictive value, PPV = positive predictive value, TN=true negatives, TP=true positives