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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: Int J Epidemiol. 2022 Jul 15;52(1):58–70. doi: 10.1093/ije/dyac143

Figure 3.

Figure 3

Independent effects of genetically predicted obesity-related traits on the risk of BC after adjusting for each confounder separately and together using multivariable Mendelian randomization. The y-axis details the genetically predicted confounder(s) for which adjustment was made, and the x-axis details the ORs and 95%CIs per 1-standard deviation (SD) increase in exposure. Asterisks (*) denote statistical significance survived false discovery rate (FDR) correction (PFDR <0.05). Total effect refers to the estimate derived from UVMR.

Abbreviations: BMI, body mass index; WHR, waist-to-hip ratio; WHRadjBMI, waist-to-hip ratio adjusted for body mass index; BC, breast cancer; ER, estrogen receptor; AAM, age at menarche; ANM, age at natural menopause; OR, odds ratio; 95%CI, 95% confidence interval.