Table 2. Independent effect of adult obesity and childhood obesity on the risk of BC using multivariable Mendelian randomization analysis.
| BC overall | ER+ | ER- | ||||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |||
| Model 1 | ||||||||
| BMI | 1.00 (0.90-1.10) | 0.96 | 0.99 (0.88-1.11) | 0.88 | 0.96 (0.82-1.12) | 0.58 | ||
| childhood BMI | 0.84 (0.77-0.93) | 3.93×10-4* | 0.86 (0.77-0.95) | 4.05×10-3* | 0.83 (0.72-0.96) | 1.43×10-2* | ||
| Model 2 | ||||||||
| WHR | 0.90 (0.82-0.98) | 1.49×10-2* | 0.90 (0.81-1.00) | 4.29×10-2 | 0.93 (0.84-1.04) | 0.20 | ||
| childhood BMI | 0.84 (0.76-0.91) | 6.57×10-5* | 0.86 (0.78-0.95) | 2.87×10-3* | 0.76 (0.68-0.85) | 6.10×10-7* | ||
| Model 3 | ||||||||
| WHRadjBMI | 0.92 (0.86-0.99) | 1.98×10-2* | 0.91 (0.84-0.98) | 1.92×10-2* | 0.96 (0.88-1.05) | 0.35 | ||
| childhood BMI | 0.80 (0.74-0.87) | 1.24×10-7* | 0.82 (0.75-0.90) | 3.40×10-5* | 0.74 (0.67-0.82) | 6.09×10-9* | ||
Model 1: independent effect of adult BMI and childhood BMI on BC; Model 2: independent effect of adult WHR and childhood BMI on BC; Model 3: independent effect of adult WHRadjBMI and childhood BMI on BC. Asterisks (*) denote statistical significance survived false discovery rate (FDR) correction (PFDR <0.05).
Abbreviations: BMI, body mass index; WHR, waist-to-hip ratio; WHRadjBMI, waist-to-hip ratio adjusted for body mass index; BC, breast cancer; ER, estrogen receptor; OR, odds ratio; 95%CI, 95% confidence interval.