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. Author manuscript; available in PMC: 2022 Sep 30.
Published in final edited form as: J Neurosci. 2022 Jul 14;42(33):6453–6468. doi: 10.1523/JNEUROSCI.0521-22.2022

Figure 4. Duplication of the Dp3Tyb region of mouse chromosome 21 orthologous with Hsa21 is sufficient to decrease amyloid-β accumulation in the AppNL-F/NL-F model.

Figure 4

(A-C) Amyloid-β deposition (82E1) in the cortex was quantified at 8-months of age in male and female mice by manual plaque counting. (A) Significantly fewer amyloid-β deposits were observed in the cortex of Dp3Tyb;AppNL-F/NL-F compared with AppNL-F/NL-F controls (F(1,18) = 12.359, p = 0.002). AppNL-F/NL-F female n = 2, male n = 7; Dp3Tyb;AppNL-F/NL-F female n = 9, male n = 5. No amyloid deposits were observed in n = 4 WT controls. (B) A non-significant trend for reduced amyloid-β deposits in the cortex was observed in Dp(10)2Yey;AppNL-F/NL-F compared with AppNL-F/NL-F controls (F(1,11) = 12.359, p = 0.077). AppNL-F/NL-F female n = 4, male n = 3; Dp(10)2Yey;AppNL-F/NL-F female n = 6, male n = 2. No amyloid-β deposits were observed in WT n = 6 and Dp(10)2Yey n = 3 controls. (C) No difference in amyloid-β deposits were observed in the cortex of Dp(17)3Yey;AppNL-F/NL-F compared with AppNL-F/NL-F controls (F(1,18) = 0.021, p = 0.885). AppNL-F/NL-F female n = 6, male n = 4; Dp(17)3Yey AppNL-F/NL-F female n = 6, male n = 6. No amyloid-β deposits were observed in WT n = 6 and Dp(17)3Yey n = 6 controls. Dp3Tyb abbreviated to Dp3, Dp(10)2Yey abbreviated to Dp10, Dp(17)3Yey abbreviated to Dp17 for clarity. Error bars show SEM, data points are independent mice