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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Radiology. 2022 Dec 20;307(1):e221145. doi: 10.1148/radiol.221145

Figure 3. Illustrative example of sampled lung areas with ex-vivo CT, micro-CT and histology.

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(A) Illustrative example of an ex vivo lung CT scan (axial view, no contrast) which was considered highly abnormal (25% healthy, 55% reticulation, 20% ground-glass opacification) (B-E). Micro-CT, histopathology (hematoxylin and eosin (H&E) and trichrome staining) of the area highlighted with a circle in A showing para-septal and interstitial fibrotic changes (5× magnification for C-E, 20× for D). (F) Illustrative example of an ex-vivo lung CT scan (no contrast) which was considered grossly healthy (80%) with mild ground-glass opacification (15%) and limited reticulation (5%) (G-J). Micro-CT and histopathology (H&E and trichrome staining) of the matched location (circle in F) showing para-septal and interstitial fibrosis. (5× magnification for H-J, 20× for I). Awy = airway, BV = blood vessel