. Author manuscript; available in PMC: 2023 Jan 21.

Published in final edited form as: JCI Insight. 2022 Dec 22;7(24):e154142. doi: 10.1172/jci.insight.154142

Table 1. Summary of plasma exposure of 8D3₁₃₀ and NIP228 with and without PMO in C57BL/6J mice following intravenous administration.

Construct	C_max (μg/mL)	AUC_last (h×μg/mL)	Clearance (mL/h/kg)
8D3₁₃₀	9,380	350,000	0.054
8D3₁₃₀-PMO	1,230	51,800	0.240
NIP228	5,230	175,000	0.078
NIP228-PMO	1,330	69,600	0.193

AUC_last, the area under the plasma concentration-time curve from time 0 to the last measured concentration.

Table 1. Summary of plasma exposure of 8D3130 and NIP228 with and without PMO in C57BL/6J mice following intravenous administration.