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. Author manuscript; available in PMC: 2023 Jan 21.
Published in final edited form as: JCI Insight. 2022 Dec 22;7(24):e154142. doi: 10.1172/jci.insight.154142

Table 2. Summary of brain and spinal cord exposure of 8D3130, 8D3130-PMO, and NIP228 in C57BL/6J mice following intravenous administration.

Construct Brain Spinal cord
Tmax (h) Cmax (μg/g) AUClast (h×μg/g) Tmax (h) Cmax (μg/g) AUClast (h×μg/g)
8D3130 24 22.6 2,180 24 12.6 1,460
8D3130-PMO 24 13 1,330 24 10.5 614
NIP228 24 2.29 263 24 1.79 28.4

Tmax, time to maximum concentration.