Table 2. Multivariable Linear Mixed Effects Regression Analysis of Pulse Rate and Blood Pressure in Malaria Following Treatment with Amodiaquine.

		Pulse Rate (beats/minute)				Systolic Blood Pressure – Supine (mmHg)				Diastolic Blood Pressure – Erect (mmHg)
		Univariable Analyses		Multivariable Analyses		Univariable Analyses		Multivariable Analyses		Univariable Analyses		Multivariable Analyses
	Number of Observations	Crude Estimate (95% CI)	p value	Adjusted Estimate (95% CI)	p value	Crude Estimate (95% CI)	p value	Adjusted Estimate (95% CI)	p value	Crude Estimate (95% CI)	p value	Adjusted Estimate (95% CI)	p value
Total plasma concentration of amodiaquine and desethylamodiaquine, per 750* nmol/litre increase	362	-19.51 (-23.10 to -15.92)	<0.0001	-14.57 (-18.22 to -10.92)	<0.0001	-18.09 (-20.99 to -15.20)	<0.0001	-12.43 (-15.95 to -8.92)	<0.0001	-10.64 (-13.03 to -8.25)	<0.0001	-10.26 (-13.11 to -7.42)	<0.0001
Body temperature change, per 1°C increase	362	9.72 (8.32 to 11.12)	<0.0001	5.65 (3.74 to 7.56)	<0.0001	4.46 (3.14 to 5.79)	<0.0001			2.97 (1.94 to 4.00)	<0.0001
Malaria	362
Yes (days 0-2)	106	-3.21 (-5.54 to -0.90)	0.0066	2.98 (0.50 to 5.46)	0.0186	-9.41 (-11.52 to -7.30)	<0.0001	-4.53 (-6.93 to -2.13)	0.0002	-1.13 (-2.84 to 0.58)	0.1958	2.91 (0.97 to 4.85)	0.0034
No (days 3-28)	256	Reference		Reference		Reference		Reference		Reference		Reference
Sex	362
Female	193	Reference		Reference		Reference				Reference
Male	169	3.06 (-4.81 to 10.93)	0.4388	4.12 (-4.17 to 12.41)	0.3232	2.52 (-3.74 to 8.78)	0.4231			4.14 (-0.80 to 9.08)	0.0985

^*Mean maximum total plasma drug concentration (rounded) after a 3-day course of amodiaquine from pharmacokinetic analysis of same study