. Author manuscript; available in PMC: 2023 Mar 16.

Published in final edited form as: Br J Clin Pharmacol. 2022 Nov 8;89(3):1176–1186. doi: 10.1111/bcp.15569

Table 3. Multivariable Linear Mixed Effects Regression Analysis of the Corrected QT Interval in Malaria Following Treatment with Amodiaquine.

		QTcS – Study-specific Correction (milliseconds)				QTcF – Fridericia Correction (milliseconds)				QTcB – Bazett Correction (milliseconds)
		Univariable Analyses		Multivariable Analyses		Univariable Analyses		Multivariable Analyses		Univariable Analyses		Multivariable Analyses
	Number of Observations	Crude Estimate (95% CI)	p value	Adjusted Estimate (95% CI)	p value	Crude Estimate (95% CI)	p value	Adjusted Estimate (95% CI)	p value	Crude Estimate (95% CI)	p value	Adjusted Estimate (95% CI)	p value
Total plasma concentration of amodiaquine and desethylamodiaquine, per 750^* nmol/litre increase	356	12.98 (8.73 to 17.16)	<0.0001	10.43 (5.92 to 15.00)	<0.0001	20.35 (15.56 to 25.15)	<0.0001	10.67 (6.13 to 15.21)	<0.0001	6.10 (1.80 to 10.38)	0.0055	10.26 (5.71 to 14.81)	<0.0001
Body temperature change, per 1°C increase	356	-5.30 (-7.12 to -3.47)	<0.0001	-3.97 (-6.49 to -1.46)	0.0021	-10.59 (-12.52 to -8.65)	<0.0001	-4.04 (-6.57 to -1.52)	0.0018	-0.374 (-2.25 to 1.50)	0.6948	-3.90 (-6.43 to -1.37)	0.0026
Sex	356
Female	187	Reference		Reference		Reference		Reference		Reference		Reference
Male	169	-16.24 (-25.48 to -7.00)	0.0009	-17.35 (-26.62 to -8.08)	0.0004	-12.72 (-22.11 to -3.34)	0.0088	-13.30 (-22.94 to -3.66)	0.0078	-19.54 (-29.00 to -10.08)	0.0001	-21.05 (-30.57 to -11.52)	<0.0001
Age, per 10-year increase	356	2.33 (-0.25 to 0.71)	0.3339	4.16 (-0.17 to 8.49)	0.0595	2.87 (-1.78 to 7.52)	0.2209	4.47 (-0.30 to 8.98)	0.0515	1.78 (-3.32 to 6.88)	0.4859	3.87 (-0.57 to 8.32)	0.0864
RR interval change, per 300-millisecond increase	356	7.50 (4.46 to 10.54)	<0.0001	-0.42 (-4.80 to 3.95)	0.8475	19.69 (16.65 to 22.74)	<0.0001	11.63 (7.25 to 16.01)	<0.0001	-3.69 (-6.75 to -0.65)	0.0177	-11.45 (-15.84 to -7.06)	<0.0001

$Q T c S = \frac{Q T}{R R^{0.42}} & Q T c F = \frac{Q T}{\sqrt[3]{R R}} & Q T c B = \frac{Q T}{\sqrt{R R}}$ , where RR is in units of seconds

Mean maximum total plasma drug concentration (rounded) after a 3-day course of amodiaquine from pharmacokinetic analysis of same study

^†

Mean change in RR interval from baseline (rounded) after last dose of amodiaquine treatment in this study