. Author manuscript; available in PMC: 2023 Jun 30.

Published in final edited form as: Stat Med. 2023 Apr 5;42(14):2496–2520. doi: 10.1002/sim.9734

Table 3. Observed data from the MUSEC trial at the interim and final analyses, with standardised test statistics and O‘Brien-Fleming (OBF) group sequential boundary (one-sided, with early stopping only for superiority).

	Interim Data		Final Data
	Placebo	CE arm	Placebo	CE arm
Number of subjects with relief from muscle stiffness	12	27	21	42
Total number of subjects	97	101	134	143
Standardised test statistic	2.540		2.718
OBF boundary	2.797		1.977