Table 2. Prospective, pediatric cohorts with repeated measures of methylation and/or imaging.
| Cohort | Age at baseline | Years of follow-up | DNAm (number of time points) | MRI (number of time points) | Sample sizea | Reference |
|---|---|---|---|---|---|---|
| Generation R | Birth | I8y | Y(n = 5) | Y (n = 4) | Up to n = 9778 | Kooijman et al. [83] |
| ALSPAC | Birth | 24 y | Y(n = 7) | Y(n = D | Up to 15,458 | Boyd et al. [84] |
| FinnBrain | Birth | 5y | Y(n = D | Y (n = 2) | Up to 3808 | Karlsson et al. [85] |
| GUSTO | Birth | 3y | Y (n = 10) | Y (n = 3) | Up to 1176 | Soh et al. [86] |
| DCHS | Birth | 6y | Y (n = 4) | Y (n = 3) | Up to 1143 | Donald et al. [87] |
| NEURON | Birth | 2y | Y (n = 2) | Y (n = 2) | Up to 80 | Moog et al. [88] |
| Fragile families | Birth | I5y | Y (n = 2) | Y(n = D | Up to 2020 | Reichmann et al. [89] |
| Lifespan Baby Connectome Project (planned) | Birth | 5y | Y(n = D | Y(n = 6) | Up to 500 | https://www.humanconnectome.org/study/lifespan-baby-connectome-project/overview |
| IMAGEN | I4y | 8y | Y (n = 2) | Y (n = 3) | Up to 2463 | Schumann et al. [90] |
| Brazilian High-Risk Cohort | 6-14 y | 6y | Y (n = 3) | Y (n = 3) | Up to 2512 | Salum et al. [91] |
a
Sample sizes refer to whole cohort, not limited to the subsample with DNAm or MRI.