Table 1.
Summary of cerebellar regions involved in different aspects of eating behaviours. Colours correspond to homeostatic (grey), motor (blue), reward (yellow) and affective (purple) functions. These areas are depicted on a cerebellar outline in Fig. 3a
| Function | Cerebellar Area | Study | Species | Fig. 3 |
|---|---|---|---|---|
| Hunger | Vermis (anterior midline) | Tataranni et al. (1999) | Human | 1 |
| Stomach stretch | Vermal lobule IX, declive, tonsil, uvula | Tomasi et al. (2009) | Human | 2 |
| Air hunger | Midline regions of central lobule | Parsons et al. (2001) | Human | 3 |
| Thirst | Vermis; Quadrangulate, Lingula | Parsons et al. (2000) | Human | 4 |
| Blood pressure and heart rate | Posterior Vermis – Lobule IX | Bradley et al. (1987) | Rabbit | 5 |
| Chewing, clenching | Vermal Lobule VI | Onozuka et al. (2002), Lin (2018b) | Human | 6 |
| Sensory inputs from the tongue | Lobules VI, VIIb/VIIIa | Boillat et al. (2020) | Human | 7 |
| Swallowing | Left posterior lobe | Suzuki et al. (2003) | Human | 8 |
| Oral behaviours (eating, grooming, gnawing) | Rostro-ventral anterior lobe vermis, fastigial nucleus, superior cerebellar peduncle | Ball et al. (1974), Berntson et al. (1973) | Rat, cat | 9 |
| Reward size encoding | Flocculus | Larry et al. (2019) | Monkey | 10 |
| Reward expectancy and omission | Lobules VI and Simplex | Wagner et al. (2017) | Mouse | 11 |
| Reward prediction learning | Lobule Simplex, Crus I and II | Heffley and Hull (2019) | Mouse | 12 |
| Prediction of reward | Lobules V, VI and Simplex | Kostadinov et al. (2019) | Mouse | 13 |
| Food and drug cue | Crus I, II and Lobules V, VI | Tomasi et al. (2015) | Human | 14 |
| Food cue reactivity + responsiveness to leptin replacement therapies | Lobule VI and Crus I | Berman et al. (2013) | Human | 15 |
| Food cue reactivity + overactivity in obesity | Lobule VI | Carnell et al. (2014) | Human | 16 |
| Decreased grey matter volume in obesity | Pyramis, Tonsil and Semilunar Lobule | Weise et al. (2017) | Human | 17 |
| Dietary disinhibition | Lobules V, VI | English et al. (2019) | Human | 18 |
| Stress | Vermis; Culmen, Declive | Yang et al. (2019) | Human | 19 |
| Altered connectivity in eating disorders | Lobule IX, X | Amianto et al. (2013) | Human | 20 |
| Fear conditioning; prediction error | Crus I and Lobule VI | Utz et al. (2015), Ernst et al. (2019) | Human | 21 |
| Fear extinction | Anterior Vermis (Lobules III-V) | Utz et al. (2015) | Human | 22 |
| Innate freezing to predatory odour | Lateral vermal lobule VIII | Koutsikou et al. (2014) | Rat | 23 |