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. Author manuscript; available in PMC: 2023 Oct 18.
Published in final edited form as: Nat Med. 2023 Aug 31;29(10):2498–2508. doi: 10.1038/s41591-023-02525-y

Extended Data Fig. 3. Change in subjective cognitive function between pre- and post-COVID.

Extended Data Fig. 3

Distribution of the change in C-PSQ-2 (assessing subjective cognitive deficits) between a pre-COVID baseline and 6 months (left) or 12 months (right) post-COVID. The dashed lines represent the mean change. In both cases, the change was, on average, significantly greater than zero indicating worsening of subjective cognitive function following COVID-19 (mean [s.e.m.] change in C-PSQ-2: 0.48 [0.04] between pre-COVID and 6 months post-COVID, p < 0.0001; and 0.40 [0.055] between pre-COVID and 12 months post-COVID-19, p < 0.0001). At six months, 43/547 participants (7.9%) had better cognition, 288 (52.7%) had no change, and 216 (39.5%) had worse cognition compared to before COVID-19. At 12 months, 12/205 participants (5.9%) had better cognition, 116 (56.6%) had no change, and 77 (37.6%) had worse cognition compared to before COVID-19.