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. Author manuscript; available in PMC: 2024 Jan 4.
Published in final edited form as: Neuron. 2023 Nov 6;111(22):3570–3589.e5. doi: 10.1016/j.neuron.2023.09.043

Figure 7. Mesoscale structure of the neuropeptide connectome.

Figure 7

(A and B) Shown are t-SNE (A) and PCA (B) plots of the adjacency matrix of the mid-range aggregate network (Euclidean distance, perplexity 30). Hubs and core clusters encompassing 112 of 166 neuropeptide rich club neurons, as well as loosely clustered periphery, are indicated by color; datapoint markers represent neuronal classification.

(C) Adjacency matrix for the mid-range neuropeptidergic network sorted in both dimensions based on neuronal clusters defined in (A) and (B).

(D) Violin plots showing indegree values for the three clusters and the periphery. Median indegree values: motor core, 139; hubs, 267; sensory core, 198; periphery, 54. Indegrees for the four groups were significantly different according to the Kruskal-Wallis test followed by Tukey-Kramer test for multiple comparisons (**p < 0.01; ****p < 0.0001).

(E) Diagram showing connections between clusters. Neurons of the motor core connect with the periphery and with the hubs; the hubs connect to almost every other neuron; the sensory core connects to the hubs and the periphery but not the motor core.