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. Author manuscript; available in PMC: 2024 Jun 3.
Published in final edited form as: Eur J Prev Cardiol. 2024 Jan 10;31(8):1015–1025. doi: 10.1093/eurjpc/zwae009

Figure 3. Trans-ethnic meta-analysis of associations of PCSK9 genetic scores and selected endpoints in CKB and UKB.

Figure 3

Estimates in UKB (open boxes) originate from data published by Roa et al22, and scaled to a corresponding 1-SD lowering of LDL cholesterol. Odds ratios in CKB (filled boxes) are estimated using logistic regression of the weighted PCSK9 genetic score, scaled to a 1-SD lowering of LDL cholesterol, calculated as an inverse-variance weighted average of region-specific estimates with adjustment for age, age2, sex, ascertainment, and region-specific principal components. Transethnic meta-analysis estimates (diamonds) are derived from inverse-variance weighted average. Cochran’s Q test was used to test for heterogeneity between the scaled UKB and CKB estimates, with a Bonferroni-adjusted significance threshold of P<0.05/7=0.0071.