Table 1. Baseline characteristics of the study population, dichotomised as non-carriers/carriers of the loss-of-function PCSK9 variant rs151193009-T.
| rs151193009 genotype | ||
|---|---|---|
| Characteristics | CC (N=69,088) |
CT/TT (N=1,826) |
| Age (years), mean (SD) | 52.1 (10.7) | 52.5 (10.9) |
| Female, % | 59.7 | 61.2 |
| Urban region, % | 45.8 | 47.2 |
| LDL-C (mmol/L), mean (SD) | 2.36 (0.69) | 1.99 (0.69) |
| Height (cm), mean (SD) | 158.8 (8.3) | 159.1 (8.2) |
| BMI (kg/m2), mean (SD) | 23.8 (3.4) | 24.0 (3.5) |
| Waist/hip ratio, mean (SD) | 0.88 (0.07) | 0.88 (0.07) |
| SBP (mmHg), mean (SD) | 131.5 (21.4) | 132.5 (21.8) |
| DBP (mmHg), mean (SD) | 78.0 (11.2) | 78.8 (11.5) |
| Physical activity (MET h/d), mean (SD) | 20.6 (14.0) | 20.6 (14.3) |
| High school or higher education, % | 21.0 | 21.8 |
| Household income ≥20,000 yuan, % | 40.1 | 40.4 |
| Current regular alcohol drinking, % | 15.5 | 15.5 |
| Current regular smoker, % | 25.9 | 24.2 |
| Stroke/TIAa, % | 1.7 | 1.7 |
| Coronary heart diseasea, % | 3.6 | 4.2 |
| Hypertension, % | 11.6 | 12.9 |
| Diabetesb, % | 6.1 | 6.2 |
| Taking statins, % | 1.9 | 1.6 |
BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; MET: metabolic equivalent of task
a
self-reported physician diagnosed.
b
self-reported physician diagnosed or screen-detected at baseline