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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Mol Ther. 2012 Sep 25;21(1):18–30. doi: 10.1038/mt.2012.200

Figure 6. Vector biodistribution and gene expression after IV injection.

Figure 6

WT C57Bl/6 mice were injected IV at 4-5 weeks old with vehicle, 1×1011 vg scAAV/MeP-GFP (+GFP), or 1×1011 vg scAAV/MeP-MECP2 (+MECP2), then sacrificed at 1 or 3 weeks post-injection. a. qPCR biodistribution of GFP or MECP2 vector genomes to major organs. b. RT-qPCR of total MECP2 (mouse + human) relative to actin. Mean ± S.E.M. are plotted, n = 2-4, with the exception of the +GFP mice at 3 weeks (n =1). Legend for both panel a and b is provided in panel a. # = not determined.