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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Eur J Hum Genet. 2012 Nov 28;21(7):779–783. doi: 10.1038/ejhg.2012.242

Table 1.

Associations between SNPs and either aPTT or APC resistance.

Trait SNP Chr1 Position2 Gene symbol3 Tested allele N Ln Effect4
(95% CI)		 Effect in secs5
(95% CI)		 p-value6
aPTT rs2545801 5 176773945 F12 A 2498 0.05
(0.04,0.06)		 1.05
(1.04,1.06)		 1.39×10−59
aPTT rs1801020 5 176769138 F12 A 2505 0.05
(0.05,0.06)		 1.05
(1.05,1.06)		 1.55×10−59
aPTT rs17876032 5 176763233 F12 G 2507 0.04
(0.03,0.04)		 1.04
(1.03,1.04)		 1.40×10−37
aPTT rs710446 3 187942621 KNG1 G 2501 −0.03
(−0.03,−0.02)		 0.97
(0.97,0.98)		 2.68×10−19
aPTT rs2228243 3 187877807 HRG G 2503 0.03
(0.02,0.04)		 1.03
(1.02,1.04)		 1.35×10−17
aPTT rs16860992 3 187876732 HRG C 2503 0.03
(0.02,0.04)		 1.03
(1.02,1.04)		 4.37×10−17
aPTT rs5030062 3 187936874 KNG1 C 2506 −0.02
(−0.03,−0.02)		 0.98
(0.97,0.98)		 3.55×10−15
aPTT rs1621816 3 187921867 KNG1 G 2500 0.02
(0.02,0.03)		 1.02
(1.02,1.03)		 2.33×10−14
aPTT rs5030028 3 187928448 KNG1 A 2502 0.03
(0.02,0.03)		 1.03
(1.02,1.03)		 3.78×10−14
aPTT rs5030023 3 187927338 KNG1 A 2508 0.03
(0.02,0.03)		 1.03
(1.02,1.03)		 4.16×10−14
aPTT rs3856930 3 187941016 KNG1 A 2506 −0.02
(−0.03,−0.02)		 0.98
(0.97,0.98)		 6.90×10−14
aPTT rs1624230 3 187921629 KNG1 A 2499 0.02
(0.02,0.03)		 1.02
(1.02,1.03)		 9.47×10−14
aPTT rs657152 9 135129086 ABO A 2507 −0.02
(−0.03,−0.01)		 0.98
(0.97,0.99)		 2.45×10−11
aPTT rs266723 3 187929741 KNG1 C 2501 0.02
(0.01,0.02)		 1.02
(1.01,1.02)		 3.31×10−10
aPTT rs7447593 5 176756743 F12 C 2504 −0.02
(−0.02,−0.01)		 0.98
(0.98,0.99)		 1.81×10−09
aPTT rs7381103 5 176770918 F12 G 2510 0.05
(0.03,0.07)		 1.05
(1.03,1.07)		 4.35×10−09
aPTT rs651007 9 135143696 ABO A 2502 −0.02
(−0.03,−0.01)		 0.98
(0.97,0.99)		 5.97×10−09
aPTT rs1042445 3 187878130 HRG A 2508 −0.02
(−0.03,−0.01)		 0.98
(0.97,0.99)		 2.27×10−08
aPTT rs1624569 3 187932763 KNG1 G 2499 0.02
(0.01,0.02)		 1.02
(1.01,1.02)		 5.15×10−08
aPTT rs2062632 3 187943875 KNG1 G 2503 0.02
(0.01,0.02)		 1.02
(1.01,1.02)		 1.04×10−07
aPTT rs2287694 5 176792899 GRK6 G 2508 0.02
(0.02,0.03)		 1.02
(1.02,1.03)		 1.39×10−07
aPTT rs4253304 4 187410565 KLKB1 C 2498 −0.01
(−0.02,−0.01)		 0.99
(0.98,0.99)		 1.67×10−07
aPTT rs13177732 5 176789531 GRK6 C 2500 −0.02
(−0.02,−0.01)		 0.98
(0.98,0.99)		 2.56×10−07
aPTT rs9898 3 187873321 HRG A 2505 0.02
(0.01,0.02)		 1.02
(1.01,1.02)		 2.61×10−07
aPTT rs2304595 4 187409274 KLKB1 A 2507 −0.01
(−0.02,−0.01)		 0.99
(0.98,0.99)		 3.60×10−07
aPTT rs5030091 3 187943571 KNG1 G 2507 0.01
(0.01,0.02)		 1.01
(1.01,1.02)		 7.29×10−07
APC-R rs6025 1 1.68E+08 F5 A 2500 −0.28
(−0.31,−0.26)		 0.76
(0.73,0.77)		 4.2×10−104
APC-R rs6682179 1 1.68E+08 F5 A 2499 −0.08
(−0.1,−0.07)		 0.92
(0.9,1.07)		 1.43×10−28
APC-R rs6427196 1 1.68E+08 F5 C 2500 −0.08
(−0.1,−0.07)		 0.92
(0.9,1.07)		 2.11×10−28
APC-R rs6009 1 1.68E+08 F5 A 2500 −0.08
(−0.1,−0.07)		 0.92
(0.9,1.07)		 1.24×10−27
APC-R rs16860992 3 1.88E+08 HRG C 2492 0.04
(0.03,0.04)		 1.04
(1.03,1.04)		 2.29×10−15
APC-R rs2228243 3 1.88E+08 HRG G 2492 0.03
(0.03,0.04)		 1.03
(1.03,1.04)		 9.55×10−15
APC-R rs9898 3 1.88E+08 HRG A 2496 0.02
(0.02,0.03)		 1.02
(1.02,1.03)		 5.26×10−11
APC-R rs2038024 1 1.68E+08 SLC19A2 C 2496 −0.03
(−0.04,−0.02)		 0.97
(0.96,0.98)		 1.75×10−09

Both aPTT and APC resistance (“traits”) are presented in this table.

1

Chromosome (“Chr”).

2

Chromosomal position.

3

Mapped gene.

4

Logged effect sizes (as tested by regression).

5

Anti-logged effect sizes (for direct interpretation), where effect is change in trait per tested allele.

6

P-value indicates strength of evidence against the null hypothesis as tested by linear regression of trait on number of tested alleles.