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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Neurosci. 2012 Aug 1;32(31):10484–10493. doi: 10.1523/JNEUROSCI.5502-11.2012

Figure 4.

Figure 4

Nicotine exposure during adulthood does not lead to lasting changes in LTP. a, Schematic representation of the experimental setup. Rats were treated with nicotine (red bar)/saline (blue bar) during adulthood, and the electrophysiological recordings took place starting 5 weeks after treatment. b, Average STDP recorded in PFC layer V pyramidal neurons from saline-treated rats (blue circles; n = 8 cells from 6 rats) and nicotine-treated rats (red circles; n = 5 cells from 5 rats) recorded 5 weeks after treatment. For pairing, a burst of five APs was used (example trace and pairing protocol are shown left; calibration and symbols are as in Fig.2). c, Summary of STDP results shown in b. The filled circles represent average EPSP slopes of last 10 min of the recordings (gray rectangle); the open circles show individual experiments.