Fig. 7.

Pharmacological inhibition of mitochondrial Ca²⁺ channels by ruthenium red (RuR). a Exemplary traces showing a decreased unitary amplitude of xl-MCC channels in the presence of 1 μM RuR in the pipette. Test potential is −100 mV. b Exemplary traces showing reduced single-channel amplitude of i-MCC channel activity by 10 μM RuR present in the pipette solution. Standard 105 mM CaCl₂-containing solutions was supplemented with 100 μM DIDS, 10 μM CsA, 10 μM CGP 37187, and 10 μM RuR. Test potential is −100 mV. c Corresponding amplitude histogram of the channel activity shown in (b) reveals decreased single-channel amplitude of i-MCC in the presence of RuR