Skip to main content
. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Invest Dermatol. 2013 Sep 13;134(3):801–808. doi: 10.1038/jid.2013.395

Figure 5. K14cre-VHL/HIF-2α mice show faster wound closure between days 1-5.

Figure 5

(a) Digital images of wounds from K14cre-VHL/HIF-2α (n=8) and wild-type (n=12) were analyzed daily throughout the closure period. The data are presented as percentage wound closure compared to the original wound size (*p<0.05). Digital photomicrographs show representative images of wound closure from days 1-9 for wild type and K14cre-VHL/HIF-2α. (b) Bacterial flora (CFU/mg tissue) were calculated from the wounds of K14cre-VHL/HIF-2α (n=3) and wild type control (n=4) during the initial 3 days post wounding. (c and d) QPCR analysis (fold change) of primers for CRAMP and MPO, F4/80 showed a significantly reduced signal in the wounds from K14cre-VHL/HIF-2α (n=3) on day 1 when compared to wild type control (n=4) (e) QPCR analysis (fold change) of NOS1-3 showed little deviation between K14cre-VHL/HIF-2α (n=3) and wild type control (n=4).