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. Author manuscript; available in PMC: 2014 Feb 24.
Published in final edited form as: J Immunol. 2014 Jan 27;192(5):2195–2201. doi: 10.4049/jimmunol.1302082

Figure 4. Induction of CD86 by IL-21 is dependent on PI3K p110δ.

Figure 4

(A) 1×106 BALB/c CD19+ B cells were cultured for 16 hours alone or in the presence of 200ng/ml IL-21 or 10ng/ml IL-4. Where indicated cultures also contained 10μM LY-294002. Histograms show CD86 expression for gated CD19+ B cells. (B) 1×106 BALB/c CD19+ B cells were cultured for 16 hours alone or in the presence of 200ng/ml IL-21 or 10ng/ml IL-4. Cells expressed the wildtype or mutant isoforms of PI3K P110δ as indicated. Histograms show CD86 expression for gated CD19+ B cells. Data are representative of 3 independent experiments.