Comparison 7.
Adverse events and other outcomes
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Mortality - All Studies | 22 | 1788 | Risk Ratio (M-H, Random, 95% CI) | 0.96 [0.49, 1.88] |
| 2 Mortality - Active vs Control | 16 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 2.1 Active vs Control | 16 | 1132 | Risk Ratio (M-H, Random, 95% CI) | 1.41 [0.66, 3.05] |
| 3 Mortality - Active vs Active | 6 | 656 | Risk Ratio (M-H, Random, 95% CI) | 0.27 [0.07, 1.08] |
| 4 Re-operation for bleeding - All Studies | 19 | 1683 | Risk Ratio (M-H, Random, 95% CI) | 0.90 [0.53, 1.53] |
| 5 Re-operation for bleeding - Active vs Control | 10 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 5.1 Active vs Control | 10 | 688 | Risk Ratio (M-H, Random, 95% CI) | 1.00 [0.45, 2.24] |
| 6 Re-operation for bleeding - Active vs Active | 9 | 995 | Risk Ratio (M-H, Random, 95% CI) | 0.83 [0.41, 1.68] |
| 7 Any infection - All Studies | 23 | 2892 | Risk Ratio (M-H, Random, 95% CI) | 0.68 [0.46, 0.99] |
| 8 Any infection - Active vs Control | 16 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 8.1 Active vs Control | 16 | 1860 | Risk Ratio (M-H, Random, 95% CI) | 0.63 [0.41, 0.96] |
| 9 Any Infection - Active vs Active | 7 | 1032 | Risk Ratio (M-H, Random, 95% CI) | 0.88 [0.37, 2.07] |
| 10 Wound complication - All Studies | 16 | 1962 | Risk Ratio (M-H, Random, 95% CI) | 0.94 [0.57, 1.55] |
| 11 Wound complication - Active vs Control | 12 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 11.1 Active vs Control | 12 | 1464 | Risk Ratio (M-H, Random, 95% CI) | 0.88 [0.49, 1.57] |
| 12 Wound complication - Active vs Active | 4 | 498 | Risk Ratio (M-H, Random, 95% CI) | 1.13 [0.43, 2.99] |
| 13 Any thrombosis - All Studies | 11 | 925 | Risk Ratio (M-H, Random, 95% CI) | 1.13 [0.48, 2.66] |
| 14 Any thrombosis - Active vs Control | 10 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 14.1 Active vs Control | 10 | 807 | Risk Ratio (M-H, Random, 95% CI) | 1.13 [0.48, 2.66] |
| 15 Stroke - All Studies | 7 | 696 | Risk Ratio (M-H, Random, 95% CI) | 0.64 [0.21, 1.98] |
| 16 Stroke - Active vs Control | 5 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 16.1 Active vs Control | 5 | 439 | Risk Ratio (M-H, Random, 95% CI) | 0.79 [0.20, 3.21] |
| 17 Stroke - Active vs Active | 2 | 257 | Risk Ratio (M-H, Random, 95% CI) | 0.43 [0.06, 2.90] |
| 18 Non-fatal myocardial infarction - All Studies | 11 | 951 | Risk Ratio (M-H, Random, 95% CI) | 0.80 [0.43, 1.46] |
| 19 Non-fatal myocardial infarction - Active vs Control | 6 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 19.1 Active vs Control | 6 | 509 | Risk Ratio (M-H, Random, 95% CI) | 0.65 [0.32, 1.31] |
| 20 Non-fatal myocardial infarction - Active vs Active | 5 | 442 | Risk Ratio (M-H, Random, 95% CI) | 1.46 [0.43, 4.88] |
| 21 Deep vein thrombosis (DVT) | 7 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 21.1 Active vs Control | 7 | 645 | Risk Ratio (M-H, Random, 95% CI) | 0.83 [0.31, 2.23] |
| 22 Hospital length of stay (LOS) - Active vs Control | 10 | Mean Difference (IV, Random, 95% CI) | Subtotals only | |
| 22.1 Active vs Control | 10 | 772 | Mean Difference (IV, Random, 95% CI) | −1.38 [−2.79, 0.03] |
| 23 Hospital length of stay (LOS) - Active vs Active | 1 | 196 | Mean Difference (IV, Random, 95% CI) | 2.8 [−2.11, 7.71] |
| 23.1 Active vs Active | 1 | 196 | Mean Difference (IV, Random, 95% CI) | 2.8 [−2.11, 7.71] |