Methods	RCT, DB, single oral dose, parallel groups. Assessed at t = 1/2, 1 hour and then hourly for 5 hrs. Medication taken when pain of moderate to severe intensity
Participants	Impacted third molar removal n = 148 Age: Adults
Interventions	DHC 30 mg, n = 49 Placebo, n = 50
Outcomes	Measures: PI (9 point scale ) nonstandard PR (5 point scale) standard Analgesic outcome: DHC 30 mg was not significantly different to placebo. 5 hr TOTPAR: DHC 30 mg: 4.2 Placebo: 2.6
Notes	Remedication allowed at t > 2 hrs. If remedicated patients were withdrawn and their PR set to zero for all further time points Withdrawals: 18 withdrew: 9 insufficient pain, 7 did not return assessment forms, 1 did not complete assessment forms, 1 postoperative complications Adverse effects: No serious adverse effects were reported and no patients withdrew as a result. DHC 30 mg: 1/49 with 1 AE Placebo: 1/50 with 3 AE Quality score: 3
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Yes	A - Adequate