Methods	RCT - methods not described.
Participants	100 women attending a hospital antenatal clinic with heartburn that was not relieved by antacids
Interventions	Intervention group: intramuscular prostigmine. Comparison group: intramuscular water.
Outcomes	Heartburn relief.
Notes
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided.
Allocation concealment (selection bias)	Unclear risk	Not stated.
Blinding (performance bias and detection bias) Women	Low risk	Placebo controlled study.
Blinding (performance bias and detection bias) Clinical staff	Low risk	Placebo controlled study.
Blinding (performance bias and detection bias) Outcome assessors	Unclear risk	Not stated.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss to follow up.