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. Author manuscript; available in PMC: 2014 Sep 16.
Published in final edited form as: Cochrane Database Syst Rev. 2009 Jul 8;(3):CD007357. doi: 10.1002/14651858.CD007357.pub2

Table 2.

Summary of outcomes: adverse events and withdrawals

Adverse events Withdrawals
Study ID Treatment Any Serious Adverse event Other
Fliedner 1984 (1) Etodolac 50 mg, n = 37
(2) Etodolac 100 mg, n = 87
(3) Etodolac 200 mg, n = 86
(4) Aspirin 650 mg, n = 83
(5) Placebo, n = 87		 At 12 h:
(1) 5/37
(2) 14/88
(3) 13/85
(4) 13/85
(5) 9/87		 None None 4 participants took medication but were excluded from analysis due to protocol violations (2) 1, (3) 1, (4) 2
Friedrich 1983 (1) Etodolac 25 mg, n = 40
(2) Etodolac 100 mg, n = 40
(3) Aspirin 650 mg, n = 39
(4) Placebo, n = 40		 At 8 h:
(1) 0/40
(2) 2/40
(3) 3/39
(4) 0/40		 None reported None reported None reported
Gaston 1984 (1) Etodolac 50 mg, n = 39
(2) Etodolac 200 mg, n = 40
(3) Aspirin 650 mg, n = 40
(4) Placebo, n = 42		 At 8 h:
(1) 0/39
(2) 0/40
(3) 1/40
(4) 0/42		 None None None
Gaston 1986 (1) Etodolac 50 mg, n = 37
(2) Etodolac 100 mg n = 38
(3) Etodolac 200 mg n = 38
(4) Aspirin 650 mg n = 38
(5) Placebo n = 38		 At 12 h:
(1) 4/37
(2) 4/38
(3) 2/38
(4) 3/38
(5) 3/38		 None reported None None
Giglio 1986 (1) Etodolac 200 mg, n = 42
(2) Etodolac 400 mg, n = 39
(3) Placebo n = 41		 At 12 h:
(1) 21/42
(2) 13/39
(3) 23/41		 (1) 1/55 (postop bleeding) (1) 1/55 (postop bleeding) None
Hersh 1999 (1) Etodolac 200 mg, n = 47
(2) Etodolac 400 mg n = 46
(3) Etodolac ER 400 mg n = 49
(4) Etodolac ER 1200 mg n = 48
(5) Placebo n = 47		 At 24 h:
(1) 20/47
(2) 17/46
(3) 13/49
(4) 19/48
(5) 15/47		 None reported None None
Hutton 1983 (1) Etodolac 100 mg, n = 44
(2) Etodolac 200 mg, n = 41
(3) Aspirin 650 mg, n = 40
(4) Placebo, n = 43		 at 12 h:
(1) 6/44
(2) 9/41
(3) 9/40
(4) 4/43		 None reported None I participant excluded from analysis due to protocol violation (confounding medication)
Nelson 1985 (1) Etodolac 50 mg, n = 41
(2) Etodolac 100 mg, n = 42
(3) Etodolac 200 mg, n = 39
(4) Aspirin 650 mg, n = 40
(5) Placebo, n = 39		 No data None reported None 3 participants excluded because withdrew consent within 1 h, 3 participants lost to follow up (did not return diaries)
Versichelen 1982 (1) Etodolac 25 mg, n = 21
(2) Etodolac 50 mg, n = 19
(3) Etodolac 100 mg, n = 20
(4) Etodolac 200 mg, n = 21
(5) Etodolac 400 mg, n = 20
(6) Aspirin 650 mg, n = 20
(7) Placebo, n = 21		 (1) 1/21
(2) 1/19
(3) 0/20
(4) 2/21
(5) 0/20
(6) 0/20
(7) 0/21		 None reported None reported 4 participants excluded from analyses for protocol violations