Methods	RCT, DB, single dose, 5 parallel groups Medication administered when baseline pain reached a moderate to severe intensity Pain assessed at 30, 60 min, then hourly to 12 h
Participants	Moderate to severe pain following removal of impacted third molars Mean age 24 years N = 384 M = 160 F = 224
Interventions	Etodolac 50 mg, n = 37 Etodolac 100 mg, n = 87 Etodolac 200 mg, n = 86 Aspirin 650 mg, n = 83 Placebo, n = 87
Outcomes	PI: non standard (5 point scale) PR: standard 5 point scale PGE: non standard (4 point scale) Adverse events: any, serious Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1 No analgesic or other potentially confounding medication within 4 h of surgery Rescue medication permitted - no further details