Comparison 1.

Radiotherapy versus no further treatment

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall survival (adjusted for prognostic factors)	1		Hazard Ratio (Random, 95% CI)	Totals not selected
2 Deaths within 5 years (unadjusted)	2	397	Risk Ratio (IV, Random, 95% CI)	0.84 [0.30, 2.36]
3 Progression-free survival (unadjusted)	1		Hazard Ratio (Random, 95% CI)	Subtotals only
4 Disease recurrence within 5 years (unadjusted)	2	397	Risk Ratio (IV, Random, 95% CI)	0.58 [0.37, 0.91]
5 Recurrence-free survival (using adjusted HR for GOG 92)	2		Hazard Ratio (Fixed, 95% CI)	0.58 [0.39, 0.88]
6 Adverse events: haematological	2	388	Risk Ratio (IV, Random, 95% CI)	2.38 [0.63, 9.05]
7 Adverse events: gastrointestinal	2	388	Risk Ratio (IV, Random, 95% CI)	7.32 [0.91, 58.82]
8 Grade 3 or 4 adverse events: Rectal/sigmoid strictures	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only
9 Grade 3 or 4 adverse events: genitourinary	2	388	Risk Ratio (IV, Random, 95% CI)	2.12 [0.54, 8.37]
10 Grade 3 or 4 adverse events: lymphoedema	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only
11 Grade 3 or 4 adverse events: hydronephrosis	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only
12 Grade 3 or 4 adverse events: neurological	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only