Methods	RCT, DB, DD, placebo and active controlled parallel-group study, 12 hour single dose phase, followed by multi-dose phase up to 96 hours. Medication administered when pain intensity was moderate to severe
Participants	Post operative total knee or hip arthroplasty surgery Male and females Mean age 64 years (SD 11.0, range 18 to 80 years) N=180
Interventions	Lumiracoxib 400 mg, n = 60 Naproxen 500 mg, n = 60 Placebo, n = 60
Outcomes	≥50% PR over six hours Time to onset of analgesia Use of rescue medication Adverse events Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1. Total = 5
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	“validated automated system”
Allocation concealment (selection bias)	Low risk	Remote allocation
Blinding (performance bias and detection bias) All outcomes	Low risk	“double dummy”