Methods	RCT, DB, DD, placebo and active controlled, parallel-group, single oral dose. Medication administered when pain intensity was moderate to severe. Study duration 12 hours
Participants	Post-operative dental surgery, third molar extraction Male and females Mean age 22 years (SD 5.0, all >17 years) N = 202
Interventions	Lumiracoxib 400 mg, n = 50 Lumiracoxib 100 mg, n = 51 Ibuprofen 400 mg, n = 51 Placebo, n = 50
Outcomes	≥50% PR over six hours Time to onset of analgesia Use of rescue medication Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1. Total = 4
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) All outcomes	Low risk	“double dummy”

DB - double blind, DD - Double Dummy, N - number of participants in study, n - number of participants in treatment arm, PR -pain relief, R - randomised, RCT - Randomised Controlled Trial, W - withdrawals