Table 1. Trials of vitamin D supplements in pregnancy.
| Trial | No. | Location | Intervention | Outcome | |
|---|---|---|---|---|---|
| Cockburn (1980) | 1139 | Scotland | 400 IU/day or | 25(OH)D maternal | ↑ |
| or placebo | Cord | ↑ | |||
| Infant | ↑ | ||||
| Brooke (1980) | 126 | UK Asian |
1,000 IU/day | Ca maternal | ↑ |
| or placebo | Cord | → | |||
| Neonatal | ↑ | ||||
| Maternal weight | ↑ | ||||
| Marya (1981) | 120 | Asian | 600,000 IU (×2); | Ca maternal | ↑ |
| Indian | 1,200 IU/day | Cord | ↑ | ||
| or placebo | ALP maternal | ↓ | |||
| Cord | ↓ | ||||
| Marya (1988) | 200 | Asian | 600,000 IU (×2); | Ca/P maternal | ↑ |
| Indian | or placebo | Cord | ↑ | ||
| ALP maternal | ↓ | ||||
| Cord | ↓ | ||||
| Delvin (1986) | 34 | France | 1,000 IU/day; | 25(OH)D cord | ↑ |
| or no vit D | Neonatal | ↑ | |||
| Mallet (1986) | 68 | France | 200,000 IU (×1); 1,000 IU/day; or no vit D |
25(OH)D maternal with both regimes | ↑ |
↑ elevation; → no change; ↓ decrease; ALP alkaline phosphatase