Table 24. The effect of maternal vitamin D status in gestation and offspring serum calcium (Ca) concentration – Observational studies.
| First Author and year |
Bias score |
Study details |
Study type |
Confounders/ adjustments |
Number of weeks gestation when 25(OH)D was measured | Mean (SD) or median (IQR) 25(OH) D concentration (nmol/l) | Mean (SD) offspring serum Ca (mmol/l) | Unadjusted regression co-efficient β (95% CI) or correlation coefficient r (95% CI) for offspring serum Ca (mmol/) per 1nmol/l increase in 25(OH)D | Adjusted regression co-efficient β (95% CI) or correlation coefficient r (95% CI) for offspring serum Ca (mmol/) per 1nmol/l increase in 25(OH)D | conclusion | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ardawi, 1997 87 | 5 (low) | Jeddah, Saudi Arabia Cohort size=264 women |
Cross- sectional |
nil | Delivery | 47.71 (15.77) 25(OH)D <20 nmol/l (inadequate) in 23% 25(OH)D>20 nmol/l (adequate) in 77% |
Mean cord Ca =2.49 (0.19) | r=0.02 (p=0.40) | No adjustments made | No significant correlation between maternal 25(OH)D measured at delivery and offspring cord Ca No difference in cord Ca if group divided according to maternal 25(OH)D using 20 nmol/l as a threshold (p>0.05) |
|
| Maternal 25(OH)D | Mean (SD) cord calcium concentration (mmol/l) | ||||||||||
| <20 (n=24) | 2.48 (0.18) | ||||||||||
| >20 (n=240) | 2.40 (0.22) | ||||||||||