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. Author manuscript; available in PMC: 2014 Aug 7.
Published in final edited form as: Health Technol Assess. 2014 Jul;18(45):1–190. doi: 10.3310/hta18450

Table 28. The effect of Vitamin D supplementation in gestation on preeclampsia – Intervention studies.

First Author,
year		 Risk of
bias		 Setting Randomisation Adjustments/
confounders
accounted for		 Number of weeks gestation when 25(OH)D3 measured Mean (SD) 25(OH)D concentration (nmol/1-unless other stated) No. of cases in un-supplemented group No. of cases in supplemented group Conclusion
Marya, 1987 132 −2 (high) Rohtak, India Randomised to either no supplement (n=200) or 375 mg/day calcium + 1200 IU Vitamin D given at 20-24 weeks until birth (n=200) Nil Not measured Not measured 18 12 No significant difference in rates of pre-eclampsia in the 2 groups (p>0.05)
Significantly reduced diastolic and systolic BP in the supplemented group at 32 and 36 weeks (p<0.001). No significant difference at 24 or 28 weeks (p value not given)