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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Mol Ther. 2014 Aug 26;22(12):2142–2154. doi: 10.1038/mt.2014.157

Figure 6. Assessment of functional GIA induced by mixed-modality AMA1 immunization regimens.

Figure 6

(a) In vitro GIA of purified IgG was assessed at 10mg/mL against 3D7 clone P. falciparum parasites. Individual data and medians are shown for each group at d0 (baseline), and then four weeks following all booster vaccinations (d84 or d140). Responses >20% are typically regarded as positive. (b) Relationship between GIA and anti-3D7 AMA1 serum IgG concentrations measured by ELISA. Non-linear regression curve is also shown (n=67). The EC50 (level of anti-3D7 AMA1 response in this ELISA assay that gives 50% GIA, indicated by the dotted line) was 69.7 μg/mL, (95% C.I. = 50.2 – 97.0).