Table 2. Model Parameters (confidence intervals of fitting) for cerebral blood flow response to hypoxia.
| CBFB (mL/100 g /min) | CBFH (mL/100 g /min) | CBFR (mL/100 g /min) | kH (/s) | kR (/s) | δH (s) | δR (s) | |
|---|---|---|---|---|---|---|---|
| All Grey Matter | 76.1 (75.5, 76.7) | 87.8 (86.7, 89.6) | 76.4 (73.8, 78.7) | 0.0035 (0.0019, 0.0046) | 0.0069 (0.002, 0.0103) | 185 (132, 230) | 20* |
| Frontal Lobe | 56.9 (56.4, 57.4) | 68.2 (66.8, 69.7) | 57.0 (53.6, 60.5) | 0.0032 (0.0018, 0.0046) | 0.005 0.0008, 0.0091) | 250 (202, 298) | 20* |
| Insula | 71.1 (70.0, 72.2) | 83.4 (82.0, 84.5) | 73.9 (71.6, 76.2) | 0.0034 (0.0017, 0.005) | 0.0132 (−0.0019, 0.0284) | 83 (12, 153) | 121 (80, 163) |
| Occipital Lobe** | 89.8 (88.9, 90.7) | 101.8 (100.6, 102.9) | 89.5 (87.9, 91.1) | 0.0035 (0.0021, 0.005) | 0.0099 (0.0038, 0.016) | 46 (−8, 100) | 20 (−10, 50) |
| Parietal Lobe** | 66.7 (66.1, 67.2) | 76.3 (75.6, 77.0) | 65.9 (62.6, 69.2) | 0.0042 (0.0027, 0.0058) | 0.0062 (0.0008, 0.0116) | 159 (115, 203) | 88 (49, 128) |
| Putamen** | 62.8 (62.1, 63.4) | 72.5 (71.4, 73.6) | 60.9 (57.6, 64.2) | 0.003 (0.0018, 0.0043) | 0.0052 (0.0012, 0.0093) | 83 (26, 140) | 30 (−10, 70) |
| Temporal Lobe | 77.4 (76.5, 78.2) | 87.1 (85.5, 88.8) | 77.1 (73.9, 80.3) | 0.0029 (0.0012, 0.0045) | 0.0062 (0.000, 0.0124) | 85 (7, 163) | 20 (−34, 74) |
| Thalamus** | 62.4 (61.8, 63.1) | 71.8 (71.0, 72.5) | 59.3 (58.0, 60.6) | 0.0044 (0.0027, 0.0062) | 0.0098 (0.0051, 0.0144) | 67 (20, 115) | 20 (−3, 43) |
CBFB = baseline CBF, CBFH = equilibrium CBF during hypoxia, CBFR = recovery CBF, kH rate constant in the transition to hypoxia, kR = rate constant in the return to normoxia, δH = delay in hypoxia response δR = delay in response upon return to normoxia, refer to Figure 1.
*
indicates a delay value fitted to be at the lower boundary, ,
**
indicates regional data based on 11 subjects.