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. Author manuscript; available in PMC: 2014 Sep 27.
Published in final edited form as: J Neurosci. 2010 Sep 8;30(36):12138–12150. doi: 10.1523/JNEUROSCI.3245-10.2010

Figure 2. Serotonin-elicited inward currents in ES animals are mediated by 5-HT2A receptors.

Figure 2

A, A voltage-clamp trace from an ES animal shows that the dominant 5-HT-elicited inward current (A1) is completely blocked by the 5-HT2 antagonist, ketanserin (A2) (2 μm; 10 min). B, A voltage-clamp trace shows the 5-HT2 partial agonist DOI (3 μm; 15 min) eliciting an inward current in an ES layer V pyramidal neuron. C, The bar chart shows that the mean peak amplitude of the inward current elicited by bath application of DOI was significantly larger in ES animals (n = 9) relative to control animals (n = 11; *p = 0.0003, paired t test). D, A voltage-clamp trace from an ES animal shows that the 5-HT-elicited inward current (D1) is completely blocked by the selective 5-HT2A antagonist MDL 100907 (D2) (30 nm, 10 min).