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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: Nature. 2014 Nov 2;517(7535):489–492. doi: 10.1038/nature13898

Extended Data Figure 5. MTUS1 is a tumour suppressor in mouse and human lung cancer.

Extended Data Figure 5

a, qRT-PCR quantification of siRNA knockdown of Mtus1 in a Kras G12D mouse lung cancer cell line (K493.1) (Wilcoxon rank-sum test). b, MTT assay shows increased growth following Mtus1 knockdown (Wilcoxon rank-sum test). Four independent trials were performed and growth was significantly increased by day 3 after knockdown in each experiment. One representative trial is shown. c, MTUS1 expression is significantly associated with overall survival in human lung adenocarcinoma, p=0.00097, X2=10.9. Analysis was performed using clinical covariates gender, age, pack years smoked, and stage.