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. Author manuscript; available in PMC: 2014 Nov 20.
Published in final edited form as: Chemistry. 2014 Mar 3;20(14):3917–3921. doi: 10.1002/chem.201400407

Table 2.

Optimization studies for the gold-catalyzed cyclization.[a]

graphic file with name emss-61040-t0009.jpg
Entry Catalyst Additive t [h] Yield [%][b]
1 11/AgNTf2 – 0.5 89
2 12/AgNTf2 – 0.5 89
3 13/AgNTf2 – 0.5 99
4 14 – 0.5 92
5 15/AgNTf2 – 0.5 96
6 16 – 30 76
7 AgNTf2 – > 24 –
8 CuI – > 24 –
9 Cu(OTf)2 – > 24 –
10 PtCl2 – > 24 –
11 – 30 mol % TFA > 24 –
12 13/AgNTf2 20 mol % 10 > 24 –
13 13/AgNTf2 20 mol % 10, 30 mol % TFA 0.5 96
[a]

General reaction conditions: 2 (0.3 mmol), AgNTf2 (10 mol%), toluene (1.7 mL), rt.

[b]

Yield of isolated 17a.