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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Genet Med. 2015 Mar 12;18(1):41–48. doi: 10.1038/gim.2015.25

Figure 2.

Figure 2

Mapping human N-terminal domain (NTD)-NPC1 mutants. Probably and possibly damaging mutations are labeled with red circles. The human NTD-NPC1 (PDB:3GKI)40 ribbon was colored according to evolutionary conservation using the ConSurf server 39; 40. Cholesterol is shown in sticks. None of the NTD-NPC1 mutants is located at cholesterol interacting residues.