Table 1.

Interspecies amino acid sequence comparisons

Molecule	Human	Canine	Sequence identity (%)	Sequence similarity (%)
CEAR	HNRPM_HUMAN	XP_005633012.1	99.3	99.5
CEA (CEACAM5)	CEAM5_HUMAN	n.d. [20]	–	–
TGF-β-RI	TGFR1_HUMAN	F1PS63_CANFA	91.8	92.2
TGF-β-RII	TGFR2_HUMAN	F1PNA9_CANFA	87.4	90.3
TGF-β-RIII	TGBR3_HUMAN	F1PIG0_CANFA	88.6	93.0
TGF-β1	TGFB1_HUMAN	TGFB1-CANFA	94.1	96.7
TGF-β2	TGFB2_HUMAN	F1PKH0_CANFA	99.5	99.8
TGF-β3	TGFB3_HUMAN	F1PR85_CANFA	88.4	89.5
NFκB1	NFκB1_HUMAN	NFκB1_CANFA	91.0	94.2
NFκB2	NFκB2_HUMAN	E2RLL2_CANFA	92.3	94.9
RelA	TF65_HUMAN	F1PCU1_CANFA	91.2	93.5

Sequences were from UniProt (http://www.uniprot.org/uniprot/) and from the National Center for Biotechnology Information (NCBI) (http://www.ncbi.nlm.nih.gov/protein). Sequences were aligned using a Needleman–Wunsch algorithm (http://www.ebi.ac.uk/Tools/psa/) with a BLOSUM 62 matrix; gap penalty and end penalty were defined as 10.0 and 0.5, respectively