Table 1. Summary of ‘driver’ CNAs present at diagnosis versus relapse detected by SNP analysis.
| chr | start | end | cytoband | CNA Loss/Gain | Diagnosis | Relapse | Genes (max 3 listed) | |
|---|---|---|---|---|---|---|---|---|
| 1 | chr6 | 78095353 | 93349377 | 6q14.1 - 6q16.1 | Loss | present | absent | IRAK1BP1, PHIP, SYNCRIP |
| 2 | chr7 | 50389071 | 50477011 | 7p12.2 | Loss | present | absent | IKZF1 |
| 3 | chr9 | 16523946 | 21901150 | 9p22.3 - 9p21.3 | Loss | present | absent | MLLT3, MTAP, FOCAD |
| 4 | chr9 | 21901150 | 22347406 | 9p21.3 | Homozygous Loss | present | absent | CDKN2A, CDKN2B |
| 5 | chr9 | 36412035 | 38493465 | 9p13.2 - 9p13.1 | Loss | present | absent | MELK, PAX5, FRMPD1 |
| 6 | chr12 | 68970862 | 69406845 | 12q15 | Gain | present | absent | RAP1B, NUP107, MDM2 |
| 7 | chr 7 | 50389060 | 50486601 | 7p12.2 | Loss | absent | present | IKZF1 |
| 8 | chr8 | 31254 | 43078119 | 8p23.3 - 8p11.21 | Loss | absent | present | ZNF596, FBXO25, DLGAP2 |
| 9 | chr9 | 6988784 | 21926959 | 9p24.1 - 9p21.3 | Loss | absent | present | MPDZ, MLLT3, MTAP |
| 10 | chr9 | 21926959 | 22200408 | 9p21.3 | Heterozygous Loss | absent | present | CDKN2A, CDKN2B |
| 11 | chr9 | 22200408 | 132070825 | 9p21.3 – 9q34.11 | Loss | absent | present | MOB3B, LINGO2, PAX5 |
| 12 | chr20 | 61305 | 62956154 | 20p13-20q13.33 | Gain | absent | present | DEFB125, DEFB126, TOP1 |
| 13 | chr21 | 15939316 | 48096958 | 21q11.2 - 21q22.3 | Loss | absent | present | CHODL,CXADR,NCAM2 |
Based on NCBI37/hg19 Assembly