FIG. 4.

Representative axial maximum intensity projections of data acquired from animals fed and dosed with DCA. Images shown concatenated with z decreasing from left to right; the reference cine images (top) span the neck (top left), heart (top middle), and anterior lobes of the liver (top right). Pyruvate was resolved in the ventricles of the heart, and additionally in the inferior vena cava. The production of hyperpolarized bicarbonate occurred predominantly in the myocardium, and in this instance it was not possible to resolve metabolism in segments distal from the chest wall. Hyperpolarized [1-¹³C] lactate was also detected after production in the myocardium, and, to a far lesser extent, the liver.