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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: Thromb Haemost. 2015 Jan 8;113(4):826–837. doi: 10.1160/TH14-08-0679

Figure 3. Platelet phenotype in cases with potentially damaging SNV in P2RY12.

Figure 3

A) The pedigree of index case 1.1, who was heterozygous for the P2Y12 R122H substitution (half back shading), showing pedigree member 1.2, also with the P2Y12 R122H substitution. B) Light transmission aggregation (LTA) responses to 10–100 μM ADP in platelet-rich plasma from 1.1 and a healthy control (HC). C) LTA responses to 30 μM ADP in 1.2. D) The pedigree of index case 2.1, who was heterozygous for the P2Y12 P258T substitution (half black shading) showing pedigree member 2.2, also with the P2Y12 P258T substitution. E) LTA response to 10–100 μM ADP in platelet-rich plasma from 2.1 and an HC. F) LTA responses to 30 μM ADP in 2.2 and a HC. G) The pedigree of the index case 3.1 who was heterozygous for the P2Y12 V207A and T223R substitutions (indicated by half black and half grey shading), showing pedigree member 3.2 with wild-type P2Y12. H) LTA response to 2–10 μM ADP in platelet-rich plasma from 1.1 and an HC. I) LTA responses to 2 μM ADP in 3.2 and a HC.