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. Author manuscript; available in PMC: 2016 Mar 3.
Published in final edited form as: Genet Med. 2015 Dec 3;18(3):265–274. doi: 10.1038/gim.2015.143

Table 2.

Demographic data and newborn estimates for HbSS at population level for each survey location based on Hardy-Weinberg equilibrium (uncorrected, q2) and accounting for excess homozygosity (corrected, q2+Fpq).

ID First Author Year Country N Survey location Population Source CBR (2012) HbS allele frequency F IS (%) HbSS newborn estimate
HWE (1) HWE+F IS (2) Ratio (2)/(1)
Sub-Saharan Africa
1 McGann 2013 Angola 36,453 Luanda 1,822,407 UN 44.3 0.120 0.62 1,169 1,222 1.0
2 Kafando 2005 Burkina Faso 2,341 Ouagadougou 1,475,223 UN 41.1 0.048 5.45 141 293 2.1
3 Moreno 1994 Burundi 382 Bujumbura 497,169 UN 44.8 0.071 0.37 111 117 1.1
4 Mutesa 2007 Burundi 637 Bujumbura 497,169 UN 44.8 0.024 4.42 12 35 2.9
5 Le Hesran 1999 Cameroon 156 Ebolowa 79,500 Wikipedia 37.5 0.135 6.46 54 76 1.4
6 Diallo 2008 Congo 1,186 Brazzaville 1,611,000 CIA 42.9 0.102 −3.16 725 524 0.7
7 Van Baelen 1969 DRC 500 Kinshasa 8,798,000 CIA 42.9 0.146 3.76 8,045 9,813 1.2
8 Lallemant 1986 DRC 146 Linzolo NA / 42.9 0.099 −3.37 / / /
9 Mutesa 2007 DRC 84 Goma 1,000,000 Wikipedia 42.9 0.024 −2.86 24 / /
10 Tshilolo 2008 DRC 4,116 Kinshasa 8,798,000 CIA 42.9 0.125 7.01 5,909 8,803 1.5
11 Tshilolo 2009 DRC 70 Other Africans 19,737 PCT 42.9 0.043 −4.48 2 0 /
12 Tshilolo 2009 DRC 579 Orientale 163,250 PCT 42.9 0.097 1.15 66 73 1.1
13 Tshilolo 2009 DRC 717 Kivu 202,159 PCT 42.9 0.079 2.80 55 73 1.3
14 Tshilolo 2009 DRC 559 Angola 157,611 PCT 42.9 0.114 2.95 89 109 1.2
15 Tshilolo 2009 DRC 932 Katanga 262,778 PCT 42.9 0.082 6.88 75 133 1.8
16 Tshilolo 2009 DRC 1,016 Not declared 286,462 PCT 42.9 0.106 6.89 138 218 1.6
17 Tshilolo 2009 DRC 3,069 Equateur 865,308 PCT 42.9 0.102 6.65 390 617 1.6
18 Tshilolo 2009 DRC 4,217 Kasai 1,188,988 PCT 42.9 0.098 4.00 486 665 1.4
19 Tshilolo 2009 DRC 10,445 Bas Congo 2,944,979 PCT 42.9 0.097 4.02 1,188 1,633 1.4
20 Tshilolo 2009 DRC 9,600 Bandundu 2,706,730 PCT 42.9 0.100 4.65 1,170 1,657 1.4
  Tshilolo∑ 2009 DRC 31,204 Kinshasa 8,798,000 CIA 42.9 0.098 4.58 3,644 5,177 1.4
21 Agasa 2010 DRC 520 Kisangani 820,000 CIA 42.9 0.126 −5.68 558 338 0.6
22 Richard-Lenoble 1980 Gabon 96 Port Gentil 142,280 Wikipedia 32.1 0.063 28.89 18 95 5.3
23 Ohene-Frempong Pers.com. Ghana 343,355 Kumasi 1,922,130 UN 31.1 0.080 3.92 383 556 1.5
24 Williams Pers.com. Kenya 15,444 Kilifi 1,109,735 UN 35.1 0.084 1.40 273 315 1.2
25 Diallo 2008 Mali 1,025 Bamako 2,037,000 CIA 47.3 0.055 2.55 296 424 1.4
26 Kulkarni 1986 Nigeria 700 Kaduna 1,524,000 CIA 41.5 0.127 10.00 1,022 1,724 1.7
27 Odunvbun 2008 Nigeria 644 Benin City 1,147,188 UN 41.5 0.132 8.71 829 1,305 1.6
28 Munyanganizi 2006 Rwanda 987 Kigali & Butare 740,383 UN 35.4 0.014 −1.39 5 0 /
29 Mutesa 2007 Rwanda 1,104 Kigali & Butare 740,383 UN 35.4 0.014 4.95 5 22 4.4
30 Oudart 1968 Senegal 345 Dakar 1,056,009 UN 38.1 0.042 7.40 71 191 2.7
31 Mbodji 2003 Senegal 479 Dakar 1,056,009 Census 38.1 0.059 25.69 142 721 5.1
32 Tchamago 2006 Senegal 944 Dakar (CHAN & HPD) 1,056,009 UN 38.1 0.052 5.87 108 225 2.1
33 Diallo 2008 Senegal 1,000 Dakar 1,056,009 UN 38.1 0.048 6.06 91 201 2.2
34 Aebischer 1990 Tanzania 92 Nassa 4,000 Study 39.3 0.054 −5.75 0 0 /
35 Aebischer 1990 Tanzania 101 Magu 20,000 Study 39.3 0.074 6.38 4 8 2.0
36 Aebischer 1990 Tanzania 30 Mwanza 150,000 Study 39.3 0.017 −1.69 2 0 /
  Aebischer∑ 1990 Tanzania 223 Nassa + Magu + Mwanza 174,000 Sum 39.3 0.058 1.98 23 31 1.3
37 North 1988 Togo 385 Lomé 1,524,000 CIA 36.7 0.110 −0.99 682 627 0.9
38 Sehbena 2002 Togo 171 Lomé 1,524,000 CIA 36.7 0.105 −3.26 620 448 0.7
North Africa
39 Diallo 2008 Tunisia 1,329 Tunis 702,330 UN 17.3 0.008 −0.76 1 0 /
40 Fattoum 2006 Tunisia 2,029 Tunis 702,330 UN 17.3 0.011 −1.22 1 0 /
41 Fattoum 2006 Tunisia 335 Nabeul 56,387 Wikipedia 17.3 0.003 −0.35 0 0 /
42 Fattoum 2006 Tunisia 264 Béja 106,441 Wikipedia 17.3 0.028 −2.92 1 0 /
  Fattoum∑ 2006 Tunisia 2,628 Tunis + Nabeul + Béja 865,158 Sum 17.3 0.012 −1.25 2 0 /
43 Hajer 2012 Tunisia 9,148 Tunis 702,330 UN 17.3 0.010 1.32 1 3 3.0
Middle East
44 Mohammed 1992 Bahrain 10,327 Manama 176,909 UN 15.5 0.077 21.21 16 58 3.6
45 Al Arrayed 2005 Bahrain 2,000 Manama 176,909 UN 15.5 0.090 1.02 22 25 1.1
46 Al Arrayed 2012 Bahrain 39,016 Manama 176,909 UN 15.5 0.073 −0.94 15 13 0.9
47 Talafih 1996 Jordan 181 Irbid 313,820 UN 27.3 0.025 −2.55 5 0 /
48 Khoriaty 2014 Lebanon 10,095 Countrywide 5,882,562 CIA 13.5 0.009 9.93 7 80 11.4
49 Alkindi 2010 Oman 5,694 Muscat 24,893 UN 21.4 0.029 7.03 0 1 /
50 Al-Awamy 1984 Saudi Arabia 1,697 Al Khobar 165,799 UN 19.6 0.028 18.78 3 19 6.3
51 Al-Awamy 1984 Saudi Arabia 2,800 Dammam 744,321 UN 19.6 0.039 10.27 22 78 3.5
52 Al-Awamy 1984 Saudi Arabia 1,124 Qatif 871,000 Wikipedia 19.6 0.109 7.80 204 334 1.6
  Al-Awamy∑ 1984 Saudi Arabia 5,621 Al Khobar + Dammam + Qatif 1,781,120 Sum 19.6 0.050 12.46 86 292 3.4
53 Nasserullah 2003 Saudi Arabia 2,154 Qatif (Non-Saudi) 78,133 PCT 19.6 0.013 6.07 0 1 /
54 Nasserullah 2003 Saudi Arabia 21,858 Qatif (Saudi) 792,867 PCT 19.6 0.132 7.40 269 401 1.5
  Nasserullah∑ 2003 Saudi Arabia 24,012 Qatif (Saudi + Non-Saudi) 871,000 Wikipedia 19.6 0.121 8.39 250 402 1.6
55 Al Hosani 2005 UAE 9,165 UAE (citizens) 1,400,000 Wikipedia 14.8 0.008 7.14 1 13 13.0
56 Al Hosani 2005 UAE 13,035 UAE (non-citizens) 7,800,000 Wikipedia 14.8 0.004 6.33 2 32 16.0
  Al Hosani∑ 2005 UAE 22,200 UAE 9,200,000 Wikipedia 14.8 0.006 6.84 5 58 11.6
57 Al Hosani 2014 UAE 542,286 UAE 9,200,000 Wikipedia 14.8 0.005 8.13 3 53 17.7
58 Al-Nood 2004 Yemen 1,500 Sana’a 1,978,286 UN 31.4 0.011 −1.11 8 0 /

N: number of newborns tested; Source: UN = United Nations Statistics Division (http://unstats.un.org/unsd/demographic/products/dyb/City_Page.htm), CIA = The World Factbook (https://www.cia.gov/library/publications/the-world-factbook/fields/2219.html), PCT = percentage, equivalent to the proportions of sub-populations in the newborn screening study, Sum = sum of sub-populations sampled in the newborn screening study. NA = not available. FIS = fixation index as a measure of homozygosity excess.