Table 4.

Top pathways in pooled meta-analysis with most significant enrichment for ADHD case CNV hits among CNVs >500kb

Pathway Name	Pathway ID	# genes	p	q-value	p(minusbest)*
IL6-mediated signalling events	NCI:62	82	1.33×10−11	9.17×10−8	0.256
TGF-beta receptor signalling	NCI:95	44	4.90×10−11	1.69×10−7	0.508
Defense response to virus	GO:51607	147	7.02×10−8	1.62×10−4	0.31
Respiratory electron transport	REACT:1019	81	1.98×10−7	3.41×10−4	0.02
Organonitrogen compound catabolic process	GO:1901565	893	9.08×10−7	1.05×10−3	3.13×10−5
Transmembrane transporter activity	GO:22857	902	9.10×10−7	1.05×10−3	8.85×10−4
Citric acid (TCA) cycle and respiratory electron transport	REACT:1240	118	1.16×10−6	1.15×10−3	0.057
Carbohydrate derivative catabolic process	GO:1901136	747	2.19×10−6	1.61×10−3	3.34×10−4
Ligand-gated ion channel activity	GO:15276	136	2.33×10−6	1.61×10−3	3.41×10−4
Methyltransferase activity	GO:8168	201	3.19×10−6	2.00×10−3	0.022
Small thymus	MGI:706	199	4.15×10−6	2.39×10−3	0.488
Transmembrane transport	GO:55085	1124	5.22×10−6	2.44×10−3	0.0028
Ion gated channel activity	GO:22839	300	5.29×10−6	2.44×10−3	4.18×10−4

^*p-value for pathway enrichment after omitting the most significant sample

Pathways which are robustly enriched (i.e. those with p(minus best)<0.05) are shown in bold.