Table 4. Effect estimates from multivariate analysis using generalized linear models.
| QoL Measures and Predictors | Effect Estimate | 95% Confidence Interval | Adjusted P Value |
|---|---|---|---|
| SF-12 MCS | |||
| Age | 1.00 | 1.00 to 1.01 | 0.91 |
| Sex | 1.03 | 0.96 to 1.11 | 0.63 |
| Time on dialysis | 1.00 | 1.00 to 1.00 | 0.83 |
| Stoke–Davies comorbidity score | 0.98 | 0.95 to 1.02 | 0.63 |
| Frailty scorea | 0.94 | 0.91 to 0.97 | <0.01 |
| HD versus PD | 0.98 | 0.92 to 1.06 | 0.87 |
| SF-12 PCS | |||
| Age | 1.00 | 0.99 to 1.00 | 0.85 |
| Sex | 1.10 | 1.00 to 1.22 | 0.23 |
| Time on dialysis | 1.00 | 1.00 to 1.00 | 0.70 |
| Stoke–Davies comorbidity score | 0.99 | 0.95 to 1.04 | 0.91 |
| Frailty scorea | 0.88 | 0.84 to 0.91 | <0.01 |
| HD versus PD | 1.03 | 0.93 to 1.13 | 0.85 |
| Illness Intrusiveness Rating Scale | |||
| Agea | 0.98 | 0.98 to 0.99 | <0.01 |
| Sex | 1.08 | 0.98 to 1.21 | 0.40 |
| Time on dialysis | 1.00 | 1.00 to 1.00 | 0.85 |
| Stoke–Davies comorbidity score | 0.99 | 0.94 to 1.03 | 0.85 |
| Frailty scorea | 1.14 | 1.09 to 1. 20 | <0.01 |
| HD versus PD | 1.07 | 0.96 to 1.19 | 0.51 |
| Barthel Index | |||
| Age | 1.00 | 0.99 to 1.01 | 0.91 |
| Sex | 1.02 | 0.93 to 1.12 | 0.89 |
| Time on dialysis | 1.00 | 1.00 to 1.00 | 0.96 |
| Stoke–Davies comorbidity score | 0.98 | 0.94 to 1.02 | 0.57 |
| Frailty scorea | 0.89 | 0.86 to 0.93 | <0.01 |
| HD versus PD | 0.98 | 0.89 to 1.08 | 0.87 |
| Symptom score | |||
| Age | 0.99 | 0.98 to 1.00 | 0.43 |
| Sex | 1.07 | 0.89 to 1.30 | 0.74 |
| Time on dialysis | 1.00 | 1.00 to 1.00 | 0.98 |
| Stoke–Davies comorbidity score | 0.99 | 0.91 to 1.07 | 0.91 |
| Frailty scorea | 1.23 | 1.13 to 1.34 | <0.01 |
| HD versus PD | 1.00 | 0.83 to 1.20 | 0.98 |
| Renal Treatment Satisfaction Questionnaire | |||
| Age | 1.00 | 1.00 to 1.00 | 0.93 |
| Sex | 1.00 | 0.95 to 1.05 | 0.96 |
| Time on dialysis | 1.00 | 1.00 to 1.00 | 0.29 |
| Stoke–Davies comorbidity score | 1.00 | 0.98 to 1.02 | 0.93 |
| Frailty score | 0.98 | 0.96 to 1.00 | 0.14 |
| HD versus PDa | 0.94 | 0.89 to 0.98 | 0.04 |
| Hospital Anxiety and Depression Scale | |||
| Age | 0.99 | 0.97 to 1.00 | 0.19 |
| Sex | 0.97 | 0.80 to 1.17 | 0.89 |
| Time on dialysis | 1.00 | 1.00 to 1.00 | 0.86 |
| Stoke–Davies comorbidity score | 1.02 | 0.94 to 1.10 | 0.87 |
| Frailty scorea | 1.21 | 1.11 to 1.31 | <0.01 |
| HD versus PD | 0.97 | 0.81 to 1.17 | 0.91 |
Effects are multiplicative for the γ-regression model (e.g., an increase of 1 U frailty score reduces the SF-12 PCS score by a factor of 0.88 [95% confidence interval, 0.84 to 0.91]; an increase of 1 U frailty score increases the symptom burden by a factor of 1.23 [95% confidence interval, 1.13 to 1.34]). QoL, quality of life; SF-12, Short Form-12; MCS, Mental Component Summary; HD, hemodialysis; PD, peritoneal dialysis; PCS, Physical Component Summary.
a
Significant predictors (P<0.05).