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. Author manuscript; available in PMC: 2016 Apr 8.
Published in final edited form as: J Physiol. 2016 Feb 4;594(14):3981–3992. doi: 10.1113/JP271588

Figure 2. Carbamylcholine perfusion and effects on ventricular electrophysiology.

Figure 2

A. Conduction velocity during CCh perfusion and apical pacing remains unchanged while there is B. a significant increase in median APD80 as determined by optical mapping of the anterior wall of the left ventricle. C. CCh perfusion results in prolongation of the APD in response to a closely coupled extra-stimulus following a drive train compared to baseline conditions (ΔF: fractional change in RH237 fluorescence). D/E. This results in a significant (*p<0.05) flattening of the electrical restitution slope (RT: restitution, max slope: steepest part of the restitution curve).