Table 4.
Resting-state functional disconnection in the remitted melancholic MDD patients vs the non-melancholic patients and HC group
| Hemisphere | Regions | Peak MNI Coordinates |
Peak | Cluster | FWE-Corrected | |||
|---|---|---|---|---|---|---|---|---|
| X | Y | Z | z Score | Size | p Value | |||
| FWE-corrected at the cluster-level over the whole brain (p<0.05) | ||||||||
|
| ||||||||
| R | Parahippocampal gyrus | 24 | −27 | −15 | 4.22 | 52 | 0.045 | |
|
| ||||||||
| FWE-corrected at the cluster-level over an a priori amygdala ROI (p<0.0071) | ||||||||
|
| ||||||||
| L | Amygdala | −24 | −6 | −15 | 3.54 | 10 | 0.006 | |
FWE, familywise error; HC, healthy control; L, left; MDD, major depressive disorder; MNI, Montreal Neurological Institute; R, right; ROI, region of interest.
1
Corresponding to approximate Bonferroni corrected p<0.05/number of ROIs to correct for the number of ROIs used in the study.