Skip to main content
. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: J Hepatol. 2015 Dec 29;64(5):1118–1127. doi: 10.1016/j.jhep.2015.12.017

Figure 6. MR1-dependent activation of blood and liver MAIT cells by professional and non-professional antigen presenting cells (APC) exposed to bacteria.

Figure 6

APC exposed to E. coli were co-cultured with MAIT cells and their activation examined by flow cytometry for CD107a, IFN-γ, TNF-α, CD40L. Dependency on MR1 or IL-12 and IL-18 was assessed by antibody blocking. Activation of blood MAIT by blood macrophages (A) and activation of liver MAIT by THP1 cells (B) and autologous intrahepatic B cells (C) were analyzed. Data are mean ± SEM (A) and median ± interquartile range (B and C). *=p<0.05; ***=p<0.001 by paired t-test. UT=untreated