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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: J Hepatol. 2015 Dec 29;64(5):1118–1127. doi: 10.1016/j.jhep.2015.12.017

Figure 7. Bacterially exposed primary human biliary epithelial cells activate both blood and liver MAIT cells in an MR1 dependent manner.

Figure 7

Biliary epithelial cells exposed to E. coli were co-cultured with sorted blood CD8+ (A and B) or liver CD3+ (C) T cells and activation of CD161++ Va7.2+ MAIT cells examined by flow cytometry for CD107a, IFNγ-,, TNFα, CD40L. Dependency on MR1 or cytokines IL-12 and IL-18 was assessed using function-blocking antibodies. Data are mean ± SEM (A and B) and median ± interquartile range (C). *=p<0.05; ***=p<0.001 by t-test. UT=untreated.